- Safe & Vault, Blacksburg
- Sandwich Shop Restaurants, Blacksburg
- Savings Banks, Blacksburg
- Scientific & Laboratory Equipment & Instruments, Blacksburg
- Scrap & Waste Materials, Blacksburg
- Screen Printing, Blacksburg
- Seafood Restaurants, Blacksburg
- Secondary Schools, Blacksburg
- Security & Surveillance System & Equipment, Blacksburg
- Security Alarm Systems - Home & Business, Blacksburg
- Security Brokers & Dealers, Blacksburg
- Security Control Systems & Monitoring, Blacksburg - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Services, Blacksburg
- Septic Tank Installation & Repair, Blacksburg - Septic Systems
- Septic Tank Pumping & Cleaning, Blacksburg - Septic Systems
- Septic Tanks & Septic Systems Contractors, Blacksburg - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems, Blacksburg - Wholesale, Dealers & Suppliers
- Sewer & Drain Cleaning & Repair, Blacksburg - Drain Cleaner & Installation Services
- Sewing & Yarn Stores & Supplies, Blacksburg
- Shirts & T-Shirts, Blacksburg
- Shoe Stores, Blacksburg - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Blacksburg
- Signs, Blacksburg
- Ski, Snowboard & Snowmobile Shop - Equipment Rental & Services, Blacksburg
- Skin Care & Cosmetology Salons, Blacksburg
- Skin Care Products & Treatments, Blacksburg
- Snacks & Desserts, Blacksburg
- Snowboard Equipment Rentals, Blacksburg
- Social Service Organizations Volunteer Services, Blacksburg
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- Social Services & Welfare, Blacksburg
- Social Workers & Services, Blacksburg
- Societies & Foundation Associations, Blacksburg
- Soil Scientists, Blacksburg
- Solar Energy Companies - Contractors, Blacksburg - Solar Panel Installation - Solar Power Systems
- Sororities, Blacksburg
- Sound Systems & Recording Equipment, Blacksburg
- Special Events & Party Supply Rental, Blacksburg
- Special Interest Schools Or Instruction, Blacksburg
- Specialty Animal Services, Blacksburg
- Specialty Stores, Blacksburg
- Speech & Hearing Specialists, Blacksburg
- Speech Pathologists, Blacksburg - Speech & Language Therapy
- Sporting Goods Equipment Rental, Blacksburg
- Sporting Goods Stores, Blacksburg
- Sports Bars & Lounges, Blacksburg
- Sports Medicine, Blacksburg - Doctors, Physicians & Surgeons
- Sportswear Clothing Stores, Blacksburg - Sports Clothes
- Staffing & Support Services, Blacksburg
- State Government, Blacksburg
- State Parks, Blacksburg
- Stock & Bond Brokers & Dealers, Blacksburg
- Stocks & Bond Brokers, Blacksburg
- Submarine Sandwich Restaurants, Blacksburg
- Surveyor Services, Blacksburg - Surveying Service
- Sushi Restaurants, Blacksburg
- Swimming Pools, Blacksburg
- Swimming Pools Repair, Service, Supplies, Sale & Installation, Blacksburg
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