- Safety & Security Systems & Consultants, Gainesville
- Salvage Yards, Junk Yards & Wrecker Service, Gainesville
- Sandwich Shop Restaurants, Gainesville
- Satellite Communication Downlinking & Uplinking, Gainesville
- Savings Banks, Gainesville
- Scrap & Waste Materials, Gainesville
- Seafood Restaurants, Gainesville
- Secondary Schools, Gainesville
- Security & Surveillance System & Equipment, Gainesville
- Security Brokers & Dealers, Gainesville
- Security Consultants, Gainesville
- Security Guard & Patrol Service, Gainesville - Bodyguard, Guard Dogs, Etc
- Security Services, Gainesville
- Shoe Repair Shops, Gainesville
- Shoe Stores, Gainesville - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Gainesville
- Siding Contractors, Gainesville - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Skin Care & Cosmetology Salons, Gainesville
- Small Appliances, Gainesville
- Smoked Meat Restaurants, Gainesville
- Smoothie Restaurants, Gainesville
- Snacks & Desserts, Gainesville
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- Social Clubs & Organizations, Gainesville
- Social Services & Welfare, Gainesville
- Societies & Foundation Associations, Gainesville
- Special Events & Party Supply Rental, Gainesville
- Special Interest Schools Or Instruction, Gainesville
- Specialty Animal Services, Gainesville
- Specialty Stores, Gainesville
- Speech & Hearing Specialists, Gainesville
- Sporting Goods Stores, Gainesville
- Sports Clubs, Gainesville
- Sportswear Clothing Stores, Gainesville - Sports Clothes
- Staffing & Support Services, Gainesville
- State Government, Gainesville
- Stationery & Office Supplies, Gainesville
- Steak House Restaurants, Gainesville
- Stocks & Bond Brokers, Gainesville
- Submarine Sandwich Restaurants, Gainesville
- Surveyor Services, Gainesville - Surveying Service
- Surveyors, Gainesville
- Swimming Lessons & Classes, Gainesville
- Swimming Pools, Gainesville
- Swimwear & Accessories Shops, Gainesville - Water Sports Equipment
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