- Sandwich Shop Restaurants, Hillsville
- Savings Banks, Hillsville
- Scrap & Waste Materials, Hillsville
- Screen Printing, Hillsville
- Sealcoating, Hillsville - Asphalt Sealcoating & Paving
- Secondary Schools, Hillsville
- Security & Surveillance System & Equipment, Hillsville
- Security Services, Hillsville
- Senior Citizens Information & Services, Hillsville
- Septic Tanks & Septic Systems Contractors, Hillsville - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Sewing & Yarn Stores & Supplies, Hillsville
- Sewing Contractors, Hillsville
- Sheriff's Department, Hillsville
- Shoe Stores, Hillsville - Mens, Womens & Kids Shoes
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- Shopping & Shopping Services, Hillsville
- Siding Contractors, Hillsville - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Social Security And Disability Attorneys & Lawyers, Hillsville
- Social Security And Disability Lawyers & Attorneys, Hillsville
- Social Services & Welfare, Hillsville
- Special Interest Schools Or Instruction, Hillsville
- Specialty Animal Services, Hillsville
- Specialty Stores, Hillsville
- Sporting Goods Stores, Hillsville
- Sports Bars & Lounges, Hillsville
- State Government, Hillsville
- Substance Abuse Clinics, Hillsville - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Surveyor Services, Hillsville - Surveying Service
- Surveyors, Hillsville
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