- Obstetricians & Gynecologists, Martinsville - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Off Road Vehicles, Martinsville
- Off Road Vehicles Parts & Accessories, Martinsville
- Office Partitions & Dividers, Martinsville
- Office Supplies, Equipment & Office Furniture Stores, Martinsville
- Oil & Gas Companies, Martinsville
- Oil & Petroleum Products, Martinsville - Merchant, Wholesalers, etc
- Oil Change & Lubrication, Martinsville - Auto Oil & Quick Lube
- Oil Industry & Oil Field Equipment & Services, Martinsville - Oil Companies
- Oil Petroleum Wholesale, Martinsville
- Oncologists, Martinsville - Cancer Doctors, Physicians & Surgeons (Oncology)
- Ophthalmologists, Martinsville - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Martinsville
- Opticians, Martinsville
- Optometrists, Martinsville - Eye Doctors, Physicians & Surgeons (Optometry)
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- Optometry Clinics, Martinsville - Eye Clinics
- Oral Surgeon, Martinsville - Dentists - Oral & Maxillofacial Surgeons
- Ornamental Greenhouses, Martinsville
- Ornamental Nursery, Martinsville
- Ornamental Nursery Services, Martinsville
- Orthodontist, Martinsville - Teeth Straightening, Invisalign & Dental Braces
- Orthopedic & Prosthetic Appliances & Shoes, Martinsville - Orthopedic Shoes
- Orthopedists, Martinsville - Orthopedic Surgery Doctors, Physicians & Surgeons
- Orthotics and Prosthetics, Martinsville
- Other Building Materials & Supplies, Martinsville
- Other Lodging, Martinsville
- Outdoor & Lawn & Garden Equipment Repair & Service, Martinsville
- Outdoor Equipment & Accessories, Martinsville
- Outdoor Furniture & Patio Furniture, Martinsville - Garden Furniture Stores
- Outpatient Services, Martinsville - Outpatient Care
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