- Obstetricians & Gynecologists, Newport News - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Occupational Health Care Professionals, Newport News
- Occupational Therapy, Newport News - Occupational Health Specialists
- Oceanographic Services, Newport News
- Off Road Vehicles, Newport News
- Off Road Vehicles Parts & Accessories, Newport News
- Office Supplies, Equipment & Office Furniture Stores, Newport News
- Oil & Gas Companies, Newport News
- Oil & Petroleum Products, Newport News - Merchant, Wholesalers, etc
- Oil Change & Lubrication, Newport News - Auto Oil & Quick Lube
- Oncologists, Newport News - Cancer Doctors, Physicians & Surgeons (Oncology)
- Opera Companies, Newport News
- Ophthalmologists, Newport News - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Goods Repair & Service, Newport News - Camera Repair
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Newport News
- Opticians, Newport News
- Optometrists, Newport News - Eye Doctors, Physicians & Surgeons (Optometry)
- Optometry Clinics, Newport News - Eye Clinics
- Oral Surgeon, Newport News - Dentists - Oral & Maxillofacial Surgeons
- Organizing Services & Products – Household & Business, Newport News
- Oriental Goods & Products Stores, Newport News
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- Ornamental Nursery, Newport News
- Ornamental Nursery Products, Newport News
- Ornamental Nursery Services, Newport News
- Orthodontist, Newport News - Teeth Straightening, Invisalign & Dental Braces
- Orthopedic & Prosthetic Appliances & Shoes, Newport News - Orthopedic Shoes
- Orthopedic Shoes, Newport News
- Orthopedists, Newport News - Orthopedic Surgery Doctors, Physicians & Surgeons
- Orthotics and Prosthetics, Newport News
- Other Building Materials & Supplies, Newport News
- Other Industrial Contractors, Newport News
- Other Lodging, Newport News
- Other Specialties, Newport News - Doctors, Physicians & Surgeons
- Outdoor & Lawn & Garden Equipment Repair & Service, Newport News
- Outdoor Equipment & Accessories, Newport News
- Outdoor Furniture & Patio Furniture, Newport News - Garden Furniture Stores
- Outerwear & Accessories Manufacturers, Newport News
- Outerwear Stores, Newport News - Jackets, Sunglasses, Hats, Caps, Coats, Gloves & More
- Outpatient Services, Newport News - Outpatient Care
- Ownership Organizations, Newport News
- Oxygen & Respiratory Equipment & Supplies, Newport News - Oxygen Concentrator, Tank, Machine, etc
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