- Sand Gravel & Aggregate, Big Stone Gap
- Sandwich Shop Restaurants, Big Stone Gap
- Savings Banks, Big Stone Gap
- Scrap & Waste Materials, Big Stone Gap
- Screen Printing, Big Stone Gap
- Search & Rescue, Big Stone Gap
- Security & Surveillance System & Equipment, Big Stone Gap
- Security Services, Big Stone Gap
- Shopping & Shopping Services, Big Stone Gap
- Snacks & Desserts, Big Stone Gap
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- Social Services & Welfare, Big Stone Gap
- Specialty Animal Services, Big Stone Gap
- Specialty Stores, Big Stone Gap
- State Government, Big Stone Gap
- Steel & Metal Goods, Big Stone Gap - Steel Distributors
- Stone & Rock Quarry, Big Stone Gap - Gravel Pit, Shale, Granite, Limestone, Crushed Rock, etc
- Storm Doors & Windows, Big Stone Gap
- Swimming Pool, Sauna & Spa Contractors, Big Stone Gap
- Swimming Pools Contractors, Big Stone Gap - Install Inground - Above Ground Pools
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