- Sand Gravel & Aggregate, Charles City
- Savings Banks, Charles City
- Scientific & Research Professionals, Charles City
- Screen Printing, Charles City
- Seafood Restaurants, Charles City
- Secondary Schools, Charles City
- Security & Surveillance System & Equipment, Charles City
- Security Services, Charles City
- Senior Citizens Service & Health Organizations, Charles City
- Service Establishment Supplies & Equipment, Charles City
- Shopping & Shopping Services, Charles City
- Social Security Counselors & Representatives, Charles City
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- Social Services & Welfare, Charles City
- Societies & Foundation Associations, Charles City
- Sod & Sodding Service, Charles City
- Specialty Animal Services, Charles City
- Specialty Stores, Charles City
- Sprinkler Alarm Systems, Charles City - Fire Sprinkler Systems
- Staffing & Support Services, Charles City
- State Government, Charles City
- Stationery & Office Supplies, Charles City
- Stationery Manufacturers, Charles City
- Steel Manufacturers, Charles City
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