- Sand Gravel & Aggregate, Gate City
- Satellite Dish Antennas & Equipment Dealers, Gate City
- Savings Banks, Gate City
- Schools For The Physically Challenged, Gate City
- Search & Rescue, Gate City
- Secondary Schools, Gate City
- Security & Surveillance System & Equipment, Gate City
- Security Alarm Systems - Home & Business, Gate City
- Security Control Systems & Monitoring, Gate City - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Services, Gate City
- Seeds & Bulbs Wholesale & Growers, Gate City
- Sharpening Service, Gate City
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- Shopping & Shopping Services, Gate City
- Siding Contractors, Gate City - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Signs, Gate City
- Social Services & Welfare, Gate City
- Special Education & Care, Gate City
- Specialty Animal Services, Gate City
- Specialty Stores, Gate City
- Sporting Goods Stores, Gate City
- State Government, Gate City
- Support Services, Gate City
- Surveyor Services, Gate City - Surveying Service
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