- Obstetricians & Gynecologists, Lexington - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Office Supplies, Equipment & Office Furniture Stores, Lexington
- Oil & Petroleum Products, Lexington - Merchant, Wholesalers, etc
- Oil Change & Lubrication, Lexington - Auto Oil & Quick Lube
- Ophthalmologists, Lexington - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Lexington
- Opticians, Lexington
- Optometrists, Lexington - Eye Doctors, Physicians & Surgeons (Optometry)
- Oral Surgeon, Lexington - Dentists - Oral & Maxillofacial Surgeons
- Ornamental Greenhouses, Lexington
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- Ornamental Nursery, Lexington
- Ornamental Nursery Services, Lexington
- Orthodontist, Lexington - Teeth Straightening, Invisalign & Dental Braces
- Other Building Materials & Supplies, Lexington
- Other Lodging, Lexington
- Outdoor & Lawn & Garden Equipment Repair & Service, Lexington
- Outdoor Furniture & Patio Furniture, Lexington - Garden Furniture Stores
- Outpatient Services, Lexington - Outpatient Care
- Oxygen & Respiratory Equipment & Supplies, Lexington - Oxygen Concentrator, Tank, Machine, etc
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