- Sandwich Shop Restaurants, Radford
- Satellite & Cable TV Equipment & Systems, Radford
- Satellite Communication Downlinking & Uplinking, Radford
- Satellite TV Service, Radford
- Savings Banks, Radford
- Scientific Services, Radford
- Scrap & Waste Materials, Radford
- Screen Printing, Radford
- Sealcoating, Radford - Asphalt Sealcoating & Paving
- Secondary Schools, Radford
- Security & Surveillance System & Equipment, Radford
- Security Brokers & Dealers, Radford
- Security Investigative Services, Radford
- Security Services, Radford
- Septic Tank Installation & Repair, Radford - Septic Systems
- Septic Tank Pumping & Cleaning, Radford - Septic Systems
- Septic Tanks & Septic Systems Contractors, Radford - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems, Radford - Wholesale, Dealers & Suppliers
- Sewing & Yarn Stores & Supplies, Radford
- Sewing Machine Repair & Service, Radford
- Sewing Machines, Equipment & Supplies, Radford
- Shopping & Shopping Services, Radford
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- Siding Contractors, Radford - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Signs, Radford
- Skin Care & Cosmetology Salons, Radford
- Skin Care Products & Treatments, Radford
- Small Appliances, Radford
- Snack Foods, Radford
- Snacks & Desserts, Radford
- Social Services & Welfare, Radford
- Societies & Foundation Associations, Radford
- Special Dies Tools Jigs & Fixtures Manufacturers, Radford
- Special Interest Schools Or Instruction, Radford
- Specialty Animal Services, Radford
- Specialty Stores, Radford
- Sporting Goods Equipment Rental, Radford
- Sporting Goods Stores, Radford
- State Government, Radford
- Steel Manufacturers, Radford
- Stove, Oven, Range & Cooktop Parts & Supplies, Radford
- Substance Abuse Services, Radford
- Sushi Restaurants, Radford
- Swimming Pool Covers & Enclosures, Radford
- Swimming Pools Supplies, Equipment & Accessories, Radford
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