- Dance Companies, Wytheville
- Deck, Patio & Gazebo Design, Building, Cleaning, Repair & Maintenance Contractors, Wytheville
- Delicatessen Grocers, Wytheville
- Delicatessen Restaurants, Wytheville
- Dentists, Wytheville
- Department Stores, Wytheville
- Dermatologists, Wytheville - Skin Doctors, Physicians & Surgeons (Dermatology)
- Diner Restaurants, Wytheville
- Dinner Theater Restaurants, Wytheville
- Direct Mail Advertising Services, Wytheville
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- Disability And Social Security Attorneys & Lawyers, Wytheville
- Discount Stores, Wytheville - Clothing, Grocery, Furniture, Etc
- Disease, Handicap & Disability Services, Organizations & Groups, Wytheville
- Divorce & Family Law Attorneys & Lawyers, Wytheville
- Doctors, Physicians & Surgeons, Wytheville
- Donuts, Wytheville
- Drinking Establishments, Wytheville
- Drug Screening Services, Wytheville
- Dry Cleaning & Laundry, Wytheville - Dry Cleaners
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