- Laboratories Dental, Wytheville
- Laboratories Medical, Wytheville
- Land Surveyor, Wytheville - Land Surveying Services
- Landscape Contractors & Designers, Wytheville
- Landscaping, Wytheville
- Landscaping Materials & Supplies, Wytheville
- Laser Printers, Wytheville - Office Supplies
- Laundry Equipment Rental & Leasing, Wytheville
- Lawn & Garden Chemicals, Insecticides & Fertilizers, Wytheville
- Lawn & Garden Equipment & Supplies, Wytheville
- Lawn & Garden Services, Wytheville
- Lawn Maintenance Services, Wytheville
- Lawn Mower Repair & Blade Sharpening Service, Wytheville
- Lawn Mowers & Power Equipment, Wytheville
- Lawyers & Attorneys, Wytheville
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- Legal & Tax Services, Wytheville
- Legal Professionals, Wytheville
- Life Insurance, Wytheville
- Lighting Fixtures & Equipment, Wytheville
- Live Theaters, Wytheville
- Livestock, Wytheville
- Livestock Auctions, Wytheville
- Livestock Auctions, Wytheville
- Loans Personal, Wytheville
- Lodging, Wytheville
- Lodging Services, Wytheville
- Logistics Freight, Wytheville
- Long Haul Trucking Companies, Wytheville
- Lutheran Church, Wytheville
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