- Radiator Coolant & Solvents, Wytheville - Engine Coolant
- Radio & Television Repair Shops , Wytheville - TV Repair
- Radio Communications Equipment & Systems , Wytheville
- Radio Equipment & Parts Stores & Dealers, Wytheville
- Radio Stations & Broadcasting Companies, Wytheville
- Radiologists, Wytheville - Radiology Doctors, Physicians & Surgeons
- Ready Mix Concrete, Wytheville - Concrete Suppliers, Dealers & Company
- Ready Mix Concrete Producers, Wytheville
- Real Estate, Wytheville - Agent, Broker & Companies
- Real Estate Agent - Property Lessors, Wytheville
- Real Estate Attorneys & Lawyers, Wytheville
- Real Estate Services, Wytheville
- Recreational Equipment Repair & Service, Wytheville
- Recycling Drop-Off Centers, Wytheville
- Recycling Scrap & Waste Materials, Wytheville - Scrap Metal, etc
- Rehabilitation Centers, Products & Services, Wytheville
- Rehabilitation Specialists, Wytheville
- Rehabilitational Job Training Services, Wytheville
- Religious Organizations, Wytheville
- Rental & Leasing Business Equipment, Wytheville
- Repair Services, Wytheville
- Research Services, Wytheville
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- Residential, Wytheville
- Residential Apartments, Wytheville
- Residential Care Facilities, Wytheville
- Restaurant & Lounge, Bar, Or Pub, Wytheville
- Restaurant Management & Consulting, Wytheville - Food Facilities Consultants
- Restaurants - Breakfast Brunch Lunch, Wytheville
- Restaurants/Food & Dining, Wytheville
- Riding & Rodeo Services, Wytheville
- Riding Equipment, Wytheville
- Rigging Service & Crane Hoisting, Wytheville
- Road Construction, Wytheville - Companies & Contractors
- Road Construction & Repair Contractors, Wytheville
- Rodeo & Equestrian Equipment & Supplies, Wytheville
- Roofing Consultants, Wytheville - Roofing Companies
- Roofing Contractors, Wytheville - Roof Repair, Cleaning, Installation & Maintenance - Roofers
- Roofing Materials & Supplies, Wytheville
- Rooming & Boarding Houses, Wytheville
- Rubber & Plastic Products, Wytheville
- Rubber Products - Manufacturers, Wytheville
- Rubber Products - Retail, Wytheville
- Rv Parks, Wytheville
- Ryder Truck Rental , Wytheville - Ryder Moving
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