- Occupational Health Care Professionals, Portsmouth
- Occupational Therapy, Portsmouth - Occupational Health Specialists
- Office Supplies, Equipment & Office Furniture Stores, Portsmouth
- Oil & Petroleum Products, Portsmouth - Merchant, Wholesalers, etc
- Oil Change & Lubrication, Portsmouth - Auto Oil & Quick Lube
- Oncologists, Portsmouth - Cancer Doctors, Physicians & Surgeons (Oncology)
- Ophthalmologists, Portsmouth - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Portsmouth
- Opticians, Portsmouth
- Optometrists, Portsmouth - Eye Doctors, Physicians & Surgeons (Optometry)
- Oral Surgeon, Portsmouth - Dentists - Oral & Maxillofacial Surgeons
- Organizing Services & Products – Household & Business, Portsmouth
- Ornamental Nursery, Portsmouth
- Ornamental Nursery Services, Portsmouth
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- Orthopedic & Prosthetic Appliances & Shoes, Portsmouth - Orthopedic Shoes
- Orthopedists, Portsmouth - Orthopedic Surgery Doctors, Physicians & Surgeons
- Other Building Materials & Supplies, Portsmouth
- Other Lodging, Portsmouth
- Other Office Supply Stores, Portsmouth
- Outboard Motors, Portsmouth
- Outboard Motors Parts & Repair, Portsmouth
- Outdoor & Lawn & Garden Equipment Repair & Service, Portsmouth
- Outdoor Equipment & Accessories, Portsmouth
- Outdoor Furniture & Patio Furniture, Portsmouth - Garden Furniture Stores
- Outpatient Services, Portsmouth - Outpatient Care
- Ownership Organizations, Portsmouth
- Oxygen & Respiratory Equipment & Supplies, Portsmouth - Oxygen Concentrator, Tank, Machine, etc
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